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class E basic helix-loop-helix protein 40; bHLHe40; class B basic helix-loop-helix protein 2; bHLHb2; differentially expressed in chondrocytes protein 1; DEC1; enhancer-of-split & hairy-related protein 2; SHARP-2; stimulated by retinoic acid gene 13 protein (BHLHE40, BHLHB2, DEC1, SHARP2, STRA13)
Function:
- may function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway
- ubiquitinated; which may lead to proteasomal degradation
- able to homodimerize or heterodimerize with TCF3/E47
- interacts with ubiquitin-conjugating enzyme UBE2I/UBC9
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 Orange domain
Compartment: nucleus
Expression:
- expressed in cartilage, spleen, intestine, lung, > heart, brain, liver, muscle & stomach
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 412 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 53-65
helix-loop-helix
NAME: helix-loop-helix
SITE: 66-108
FOR-BINDING-VIA: helix-loop-helix
Orange {142-175}
Ser phosphorylation site {S383}
Database Correlations
OMIM 604256
UniProt O14503
PFAM correlations
Entrez Gene 8553
Kegg hsa:8553
References
UniProt :accession O14503