Cl- channel

- chloride channels have several functions including a) regulation of cell volume b) membrane potential stabilization c) signal transduction d) transepithelial transport Structure: - the CLC channel family contains both chloride channels & proton-coupled anion transporters that exchange chloride or another anion for protons - the absence of conserved gating Glu is typical for family members that function as channels (putative)

Specific

anion exchange protein 3 (neuronal band 3-like protein, cardiac/brain band 3-like protein, CAE3/BAE3, solute carrier family 4 member 3, SLC4A3, SLC2, AE3) anoctamin-1; transmembrane protein 16A; discovered on gastrointestinal stromal tumors protein 1; oral cancer overexpressed protein 2; tumor amplified & overexpressed sequence 2 (TMEM16A, DOG1, ORAOV2, TAOS2, ANO1) band 3 anion transport protein; anion exchange protein 1; anion exchanger 1; AE 1; solute carrier family 4 member 1; CD233 (SLC4A1, AE1, DI, EPB3) band 3-related protein; anion exchange protein 2; anion exchanger 2; AE 2; non-erythroid band 3-like protein; BND3L; solute carrier family 4 member 2 (SLC4A2, AE2 ,EPB3L1, HKB3, MPB3L) brain-derived voltage-dependent anion channel-1 Ca+2-dependent Cl- channel chloride channel protein 2; ClC-2 (CLCN2) chloride channel protein 3; H+/Cl(-) exchange transporter 3; chloride transporter ClC-3; ClC-3 (CLCN3) chloride channel protein 4; H+/Cl- exchange transporter 4; chloride transporter ClC-4; ClC-4 (CLCN4) chloride channel protein ClC-Ka; chloride channel Ka; ClC-K1 (CLCNKA) chloride channel protein ClC-Kb; chloride channel Kb; ClC-K2 (CLCNKB) chloride channel protein-1; chloride channel protein, skeletal muscle; ClC-1 (CLCN1, CLC1) chloride transport protein 6; chloride channel protein 6; ClC-6 (CLCN6 KIAA0046) Cl- channel CLIC-like protein 1 (mid-1-related chloride channel protein 1, CLCC1, KIAA076, MCLC) cystic fibrosis transmembrane conductance regulator; CFTR; cAMP-dependent chloride channel; ATP-binding cassette transporter sub-family C member 7 (CFTR ABCC7) GABA-A receptor glycine receptor H+/Cl(-) exchange transporter 5; chloride transporter ClC-5; chloride channel protein 5; ClC-5 (CLCN5, CLCK2, NPHL2, DENTS) H+/Cl- exchange transporter 7; chloride channel protein 7; ClC-7 (CLCN7) stilbene-sensitive Cl- channel voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)

General

ion channel plasma membrane protein

Properties

COMPARTMENT: plasma membrane MOTIF: membrane region ION-PERMEABILITY: Cl-

References

UniProt :accession P51788