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casein kinase 2-alpha chain (CSNK2A1)
Function:
- enzyme catalytic subunit of casein kinase 2
- the alpha & alpha' chains of casein kinase 2 are catalytically active by themselves, structurally analogous, but encoded by separate genes [1]
- interacts with RNPS1
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily
- contains 1 protein kinase domain
General
enzyme catalytic subunit
nuclear protein
serine/threonine kinase
Properties
SIZE: MW = 42-44 kD
entity length = 391 aa
MOTIF: kinase domain
SITE: N-TERMINAL
MOTIF: ATP-binding site
NAME: ATP-binding site
MOTIF: tyrosine residue {X}
serine residue {X+1}
nuclear translocation signal {K73}
MOTIF-SEQUENCE: KKKK
Thr phosphorylation site {T128}
MOTIF-SEQUENCE: TLTD
specific amino acid-enriched region {H148-H166}
MOTIF: histidine residue (4)
Thr phosphorylation site {T344}
FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1
Thr phosphorylation site {T360}
FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1
Ser phosphorylation site {S362}
FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1
Ser phosphorylation site {S370}
FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1
STATE: active state
Database Correlations
OMIM 115440
UniProt P68400
Pfam PF00069
Entrez Gene 1457
Kegg hsa:1457
ENZYME 115440
References
- Allende JE, Allende CC.
Protein kinases. 4. Protein kinase CK2: an enzyme with
multiple substrates and a puzzling regulation.
FASEB J. 1995 Mar;9(5):313-23. Review.
PMID: 7896000
Component-of
casein kinase 2