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casein kinase 2-alpha' chain (CSNK2A2)
Function:
- enzyme catalytic subunit of casein kinase 2
- the alpha & alpha' chains of casein kinase 2 are catalytically active by themselves, structurally analogous, but encoded by separate genes [1].
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily
- contains 1 protein kinase domain
General
enzyme catalytic subunit
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 350 aa
MW = 41 kD
MOTIF: kinase domain
SITE: 40-325
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 46-54
ATP-binding site
NAME: ATP-binding site
SITE: 69-69
aspartate residue {D157}
STATE: active state
Database Correlations
OMIM 115442
UniProt P19784
Pfam PF00069
Entrez Gene 1459
Kegg hsa:1459
ENZYME 2.7.11.1
References
- Allende JE, Allende CC.
Protein kinases. 4. Protein kinase CK2: an enzyme with
multiple substrates and a puzzling regulation.
FASEB J. 1995 Mar;9(5):313-23. Review.
PMID: 7896000
Component-of
casein kinase 2