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citric acid/lactic acid/potassium bitartrate (Phexxi, Evofem)
1) indications:
- on demand non-hormonal vaginal contraceptive
Dosage:
- 5 grams of Phexxi vaginal gel up to 1 hour prior to intercourse
Adverse effects:
- vulvovaginal burning sensation
- vulvovaginal pruritus
- vulvovaginal mycotic infection
- urinary tract infection
- bacterial vaginosis
- vaginal discharge
- dysuria
- vulvovaginal pain
Mechanism of action:
- vaginal pH regulator
General
contraceptive
pharmacologic combination
References
- Franki L
FDA Approves Phexxi for Use as On-Demand Contraceptive.
Medscape - May 26, 2020.
- From The Medical Letter on Drugs and Therapeutics August 24/31, 2021
Phexxi-A Nonhormonal Contraceptive Gel
JAMA. 2021;326(8):763-764
https://jamanetwork.com/journals/jama/fullarticle/2783427
Components
citrate (citric acid)
lactic acid (Lac-Hydrin)
potassium bitartrate; potassium hydrogen tartrate; KC4H5O6; cream of tartar