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citrate synthase, mitochondrial; NADH cytochrome C reductase (CS)
Function:
- carbohydrate metabolism; tricarboxylic acid cycle
acetyl-CoA + H2O + oxaloacetate citrate + CoA
Structure:
- homodimer (putative)
- belongs to the citrate synthase family
Compartment: mitochondria matrix
Expression:
- citrate synthase is found in nearly all cells capable of oxidative metabolism
Laboratory:
- citrate synthase in amniotic fluid
- citrate synthase in amniotic fluid cells
- citrate synthase in fibroblasts
- citrate synthase in leukocytes
- citrate synthase in tissue
Interactions
molecular events
Related
ATP citrate lyase (citrate cleavage enzyme, ACLY)
citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
General
citric acid cycle enzyme
ketoacid-lyase
oligomerizing protein
Properties
SIZE: entity length = 466 aa
MW = 52 kD
COMPARTMENT: mitochondrial matrix
MOTIF: histidine residue {H301}
histidine residue {H347}
aspartate residue {D402}
Database Correlations
OMIM 118950
UniProt O75390
Pfam PF00285
Entrez Gene 1431
KEGG correlations
ENZYME 2.3.3.1
References
- Wikipedia: Citrate synthase
https://en.wikipedia.org/wiki/Citrate_synthase
- UniProt :accession O75390