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cistauosis

Pathology: - formation of a pathologic form of tau (cis P-tau) damages cellular infrastructure & leads to neuronal apoptosis - over time, cistauosis spreads to other neurons

Related

microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau) paired helical filament (PHF)

General

pathologic process

References

  1. Kondo A et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature 2015 Jul 23; 523:431 PMID: 26176913