cisplatin resistance-associated overexpressed protein; cAMP regulatory element-associated protein 1; CRE-associated protein 1; CREAP-1; Luc7A; okadaic acid-inducible phosphoprotein OA48-18 (CROP, CREAP1, LUC7L3, O48)

Function: - binds cAMP regulatory element DNA sequence - role in RNA splicing (putative) - may interact with SFRS1 & form homodimers - phosphorylated in vitro by SRPK1, SRPK2 & CLK1 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the Luc7 family Compartment: - nucleus speckle - subnuclear localization is affected by cisplatin Alternative splicing: named isoforms=2 Expression: - widely expressed - highest levels in heart, brain, pancreas, thymus, ovary, small intestine, peripheral blood leukocytes, cerebellum, putamen, pituitary - lowest levels in lung, liver and kidney - also expressed in fetal tissues, including brain, heart, kidney, thymus, lung

General

DNA-binding protein phosphoprotein

Properties

SIZE: MW = 51 kD entity length = 432 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S110} coiled coil {124-181} glutamate-rich region {228-282} MOTIF: glutamate residue (SEVERAL) arginine/serine-rich region (RS domain) {235-395} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL) Ser phosphorylation site {S333} Ser phosphorylation site {S335} Ser phosphorylation site {S425} Thr phosphorylation site {T429} Ser phosphorylation site {S431}

Database Correlations

UniProt O95232 Pfam PF03194

References

UniProt :accession O95232