circadian clock oscillator

Structure: - consists of: - CRY proteins - hCLOCK or NPAS2 - BMAL1 or BMAL2 - CSNK1D &/or CSNK1E - TIMELESS - PER proteins

Properties

SUBUNITS: neuronal PAS domain-containing protein 2 COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 10-22 helix-loop-helix NAME: helix-loop-helix SITE: 23-60 FOR-BINDING-VIA: helix-loop-helix PAS domain {82-152} PAS domain {237-307} PAC domain {311-354} timeless homolog COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {661-688} MOTIF: glutamate residue (SEVERAL) Thr phosphorylation site {T1089} Ser phosphorylation site {S1149} Ser phosphorylation site {S1173} period circadian protein aryl hydrocarbon receptor nuclear translocator-like protein 1 COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 73-85 helix-loop-helix NAME: helix-loop-helix SITE: 86-126 FOR-BINDING-VIA: helix-loop-helix PAS domain {143-215} PAS domain {326-396} PAC domain {401-444} casein kinase 1 delta COMPARTMENT: cytoplasm STATE: active state MOTIF: kinase domain SITE: 9-277 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 15-23 ATP-binding site NAME: ATP-binding site SITE: 38-38 aspartate residue {D128} Autoinhibitory {317-342} MOTIF: Ser phosphorylation site {S331} Ser phosphorylation site {S350} Ser phosphorylation site {S382} casein kinase 1 epsilon COMPARTMENT: cytoplasm STATE: active state MOTIF: kinase domain SITE: 9-277 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 15-23 ATP-binding site NAME: ATP-binding site SITE: 38-38 aspartate residue {D128} Thr phosphorylation site {T362} Ser phosphorylation site {S363}

References

UniProt :accession Q99743

Components

aryl hydrocarbon receptor nuclear translocator-like protein 1; basic-helix-loop-helix-PAS protein MOP3; brain & muscle ARNT-like 1; class E basic helix-loop-helix protein 5; bHLHe5; member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3 (ARNTL, BHLHE5, BMAL1, MOP3, PASD3) casein kinase 1 delta (CSNK1D) casein kinase 1 epsilon (CSNK1E) neuronal PAS domain-containing protein 2 (neuronal PAS2, member of PAS protein 4, basic-helix-loop-helix-PAS protein MOP4, NPAS2, MOP4) period circadian protein (hPER) timeless homolog; hTIM (TIMELESS TIM TIM1 TIMELESS1)