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chymotrypsin (alpha chymotrypsin)
Function:
- digestive enzyme, protease
- cleaves peptides at the carboxyl side of Tyr, Trp, Phe
- over time, chymotrypsin hydrolyzes other amide bonds,
- particulary those with leucine as the carboxyl donor
- formed after cleavage of zymogen chymotrypsinogen by trypsin
- cleaves C-terminal Phe, Trp, Tyr, Leu, Met
Expression:
- synthesized in the pancreas as zymogen chymotrypsinogen,
Pharmacology: see alpha-Chymar (Zolyse, chymotrypsin ophthalmic)
Specific
alpha-Chymar (Zolyse, chymotrypsin ophthalmic)
chymotrypsin-B2 (CTRB2)
chymotrypsin-C; caldecrin (CTRC, CLCR)
chymotrypsinogen B; contains: chymotrypsin B chain A, chymotrypsin B chain B, chymotrypsin B chain C (CTRB1, CTRB)
General
secreted protein
serine protease trypsin family
Properties
COMPARTMENT: extracellular compartment
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
Database Correlations
OMIM 118890
ENZYME 3.4.21.1
References
- OMIM :accession 118890
- Wikipedia, chymotrypsin
http://en.wikipedia.org/wiki/chymotrypsin