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chronic bullous disease of childhood
Immunologically identical to linear IgA bullous dermatosis.
Pathology:
1) subepidermal bulla
2) IgA deposition in a linear pattern along the epidermal basement membrane with or without C3 & IgG deposition
Laboratory:
1) skin biopsy: direct immunofluorescence
2) serum IgA antibasement membrane antibodies detected by indirect immunofluorescence
a) routine serum testing generally performed with monkey esophagus as substrate
b) sensitivity increased by use of NaCl-split human skin as substrate
Management:
1) systemic corticosteroids
2) dapsone
3) sulfapyridine
Related
dapsone (Avlosulfon)
glucocorticoid
linear IgA bullous dermatosis (IgA pemphigoid)
sulfapyridine
General
vesiculobullous dermatitis
chronic skin disease (chronic dermatologic disorder, chronic dermatopathy, chronic dermatosis)
References
Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 168