chromosome transmission fidelity protein 8 homolog isoform 2; decreased expression in renal & prostate cancer protein (CHTF8, DERPC)

Function: - may be tumor suppressor - inhibits prostate tumor cell growth, when overexpressed Structure: belongs to the DERPC family Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed - abundant expression in kidney, skeletal muscle, testis, liver, ovary, & heart - moderate expression in prostate Pathology: - expression is significantly reduced in renal cancer & prostate cancer - no differential expression in breast cancer cells, between lobular carcinoma of the breast & normal lobules Genetics: - found in a common chromosomal region of deletion in breast cancer

Properties

SIZE: entity length = 524 aa MW = 51 kD COMPARTMENT: cell nucleus FORM: chromosome transmission fidelity protein 8 homolog isoform 2 MOTIF: proline-rich region SITE: 4-524 MOTIF: proline residue (SEVERAL) glycine-rich region {101-328}

Database Correlations

OMIM 613202 UniProt P0CG12

References

UniProt :accession P0CG12