chromosome transmission fidelity protein 18 homolog (hCTF18, CHTF18, CTF18)

Function: - chromosome cohesion factor involved in sister chromatid cohesion & fidelity of chromosome transmission - component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC) - CTF18 then interacts directly with CTF8, which in turn interacts with DCC1 - CTF18 interacts with SMC1A & RAD21 Structure: - belongs to the activator 1 small subunits family CTF18 subfamily Compartment: - nucleus - associates with chromatin during S phase Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 975 aa MW = 107 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S74} ATP-binding site NAME: ATP-binding site SITE: 374-381 Ser phosphorylation site {S871}

Database Correlations

UniProt Q8WVB6 Pfam PF00004 Kegg hsa:6392

References

UniProt :accession Q8WVB6