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chromosome passenger complex
Function:
1) acts as a key regulator of mitosis
2) essential functions at the centromer
- ensures correct chromosome alignment & segregatio
- required for chromatin-induced microtubule stabilization & spindle assembly
Structure:
- consists of:
- AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin, INCENP
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: serine/threonine protein kinase 12
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
Tyr phosphorylation site {Y12}
Thr phosphorylation site {T16}
Thr phosphorylation site {T35}
Ser phosphorylation site {S45}
Ser phosphorylation site {S61}
Ser phosphorylation site {S62}
Thr phosphorylation site {T64}
kinase domain
SITE: 77-327
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 83-91
Tyr phosphorylation site {Y92}
ATP-binding site
NAME: ATP-binding site
SITE: 106-106
aspartate residue {D200}
Ser phosphorylation site {S227}
Thr phosphorylation site {T232}
Thr phosphorylation site {T236}
Ser phosphorylation site {S313}
STATE: active state
baculoviral IAP repeat-containing protein 5
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: BIR {18-88}
MOTIF: Thr phosphorylation site {T34}
Zn+2-binding site
SITE: 57-57
Zn+2-binding site
SITE: 60-60
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 84-84
borealin
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: centromere localization {1-88}
MOTIF: Ser phosphorylation site {S15}
Ser phosphorylation site {S23}
Thr phosphorylation site {T106}
Ser phosphorylation site {S110}
glutamate-rich region {125-133}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S154}
Ser phosphorylation site {S164}
Ser phosphorylation site {S165}
Thr phosphorylation site {T189}
Ser phosphorylation site {S194}
Thr phosphorylation site {T204}
Ser phosphorylation site {S219}
Ser phosphorylation site {S244}
Ser phosphorylation site {S274}
inner centromere protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S50}
Ser phosphorylation site {S72}
Tyr phosphorylation site {Y73}
Ser phosphorylation site {S91}
Ser phosphorylation site {S93}
Ser phosphorylation site {S94}
Ser phosphorylation site {S103}
Ser phosphorylation site {S106}
Ser phosphorylation site {S119}
Ser phosphorylation site {S142}
Ser phosphorylation site {S143}
Thr phosphorylation site {T145}
Ser phosphorylation site {S148}
Thr phosphorylation site {T150}
Thr phosphorylation site {T195}
Ser phosphorylation site {S197}
Thr phosphorylation site {T199}
Thr phosphorylation site {T213}
Ser phosphorylation site {S214}
Ser phosphorylation site {S218}
Thr phosphorylation site {T219}
Ser phosphorylation site {S230}
Ser phosphorylation site {S235}
Thr phosphorylation site {T239}
Ser phosphorylation site {S263}
Ser phosphorylation site {S269}
Ser phosphorylation site {S275}
Ser phosphorylation site {S291}
Thr phosphorylation site {T292}
Thr phosphorylation site {T294}
Ser phosphorylation site {S296}
Thr phosphorylation site {T298}
Ser phosphorylation site {S306}
Ser phosphorylation site {S311}
Ser phosphorylation site {S312}
Ser phosphorylation site {S314}
Ser phosphorylation site {S350}
Ser phosphorylation site {S373}
Ser phosphorylation site {S400}
Thr phosphorylation site {T406}
Ser phosphorylation site {S411}
Thr phosphorylation site {T412}
Ser phosphorylation site {S420}
Ser phosphorylation site {S421}
Thr phosphorylation site {T424}
Ser phosphorylation site {S446}
Ser phosphorylation site {S458}
Ser phosphorylation site {S476}
Thr phosphorylation site {T478}
Ser phosphorylation site {S480}
Ser phosphorylation site {S481}
Thr phosphorylation site {T507}
Thr phosphorylation site {T509}
Ser phosphorylation site {S510}
Ser phosphorylation site {S514}
coiled coil {528-791}
Thr phosphorylation site {T793}
Ser phosphorylation site {S798}
Tyr phosphorylation site {Y822}
Ser phosphorylation site {S828}
Ser phosphorylation site {S831}
Thr phosphorylation site {T832}
Thr phosphorylation site {T892}
Ser phosphorylation site {S893}
Ser phosphorylation site {S894}
Ser phosphorylation site {S899}
Ser phosphorylation site {S914}
References
UniProt :accession O60447, Q53HL2
Components
baculoviral IAP repeat-containing protein 5; apoptosis inhibitor survivin; apoptosis inhibitor 4 (BIRC5, API4, IAP4)
borealin (Dasra-B, hDasra-B, cell division cycle-associated protein 8, pluripotent embryonic stem cell-related gene 3 protein, CDCA8, PESCRG3)
inner centromere protein (INCENP)
serine/threonine protein kinase 12; Aurora kinase B; Aurora- & IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; serine/threonine protein kinase aurora-B (AURKB, AIK2, AIM1, ARK2, STK12)