Chromosome-associated kinesin KIF4B (chromokinesin-B, KIF4B)

Function: - motor protein - translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone & midbody & for successful cytokinesis. - may play a role in mitotic chromosomal positioning & bipolar spindle stabilization Structure: - belongs to the kinesin-like protein family, homokinesin subfamily - contains 1 kinesin-motor domain Compartment: nucleus matrix (putative) Expression: specifically expressed in testis

General

microtubule-associated protein (MAP) nuclear protein

Properties

SIZE: entity length = 1234 aa MW = 140 kD COMPARTMENT: cell nucleus MOTIF: kinesin motor domain SITE: 1-349 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 88-95 binding site FOR-BINDING-OF: microtubule coiled coil {350-999} PRC1 interaction {663-1234} MOTIF: nuclear translocation signal {793-798} Globular {1000-1234}

Database Correlations

UniProt Q2VIQ3 Pfam PF00225

References

UniProt :accession Q2VIQ3