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chromosomal-loop
There are 5 levels of folding of DNA in eukaryotic chromosomes. The chromosomal loop represents the 3rd level of DNA folding. Nucleosomes (1st level of folding) are organized into solenoids (2nd level of folding). The solenoids in turn are folded into loops (3rd level of folding), which form attachment sites to the nuclear matrix at their base. Chromosomal loops in turn form hexameric rosette structures of 300 Kbp also known radial arrays.
General
DNA motif
macromolecular complex
Properties
SIZE: entity length = 30 KB
WIDTH = 90 NM
HEIGHT = 60 NM
COMPARTMENT: cell nucleus
MOTIF: scaffold associated region
NAME: scaffold associated region
References
- Manuelidis L.
A view of interphase chromosomes.
Science. 1990 Dec 14;250(4987):1533-40. Review.
PMID: 2274784
- Filipski J, Leblanc J, Youdale T, Sikorska M, Walker PR.
Periodicity of DNA folding in higher order chromatin structures.
EMBO J. 1990 Apr;9(4):1319-27.
PMID: 2323342
Component-of
chromosomal radial array or rosette
Components
solenoid