Search
secretogranin-1; chromogranin-B; CgB; secretogranin I; SgI; contains: GAWK peptide; CCB peptide (CHGB, SCG1)
Function:
- neuroendocrine secretory granule protein
- may be the precursor for other biologically active peptides
- extensively processed by limited proteolysis at conserved basic residues
- alternative processing are seen in different tissues (putative)
Structure:
- belongs to the chromogranin/secretogranin protein family
Compartment:
- secreted
- neuroendocrine & endocrine secretory granules
Expression:
- expressed in the adrenal medulla, & in pheochromocytoma
- not expressed in liver
General
chromogranin; secretogranin;granin
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 677 aa
MW = 78 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C36}
MODIFICATION: cysteine residue {C57}
cysteine residue {C57}
MODIFICATION: cysteine residue {C36}
Thr phosphorylation site {T79}
Ser phosphorylation site {S99}
Ser phosphorylation site {S100}
Thr glycosylation site {T116}
Ser phosphorylation site {S149}
glutamate-rich region {163-171}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S182}
Ser phosphorylation site {S183}
Ser phosphorylation site {S259}
Ser phosphorylation site {S263}
Ser phosphorylation site {S293}
Ser phosphorylation site {S294}
Ser phosphorylation site {S311}
Ser phosphorylation site {S335}
Ser phosphorylation site {S377}
Ser phosphorylation site {S380}
Ser phosphorylation site {S405}
Ser phosphorylation site {S533}
Ser phosphorylation site {S534}
Ser phosphorylation site {S617}
Ser phosphorylation site {S626}
Ser phosphorylation site {S631}
MISC-INFO: ISOELECTIC_POINT 5.1
Database Correlations
OMIM 118920
UniProt P05060
Pfam PF01271
Entrez Gene 1114
Kegg hsa:1114
References
- Huttner WB, Gerdes HH, Rosa P.
The granin (chromogranin/secretogranin) family.
Trends Biochem Sci. 1991 Jan;16(1):27-30. Review.
PMID: 2053134
- Andrews BS.
Is the WKS motif the tissue-factor binding site for coagulation
factor VII?
Trends Biochem Sci. 1991 Jan;16(1):31-6. Review.
PMID: 2053135
- Entrez Gene :accession 1114
- UniProt :accession P05060