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chromogranin-A; CgA; secretogranin-A; pituitary secretory protein I; SP-I; contains: vasostatin-1; vasostatin-2; EA-92; ES-43; pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37 (CHGA)
Function:
- pancreastatin strongly inhibits glucose induced insulin release from the pancreas
- sulfated on Tyr &/or contains sulfated glycans
- O-glycosylated with core 1 or possibly core 8 glycans
- interacts with SCG3 (putative)
Structure:
- belongs to the chromogranin/secretogranin protein family
Compartment:
- cytoplasmic vesicle
- secretory vesicle lumen, secretory vesicle membrane (putative)
- secreted; associated with secretory granule membrane through interaction with SCG3 that in turn binds to cholesterol- enriched lipid rafts (putative)
Expression:
- widespread distribution in endocrine organs
- originally found in adrenal medulla
- present in alpha cells of pancreatic islets
Notes: binds Ca+2 with a low-affinity
Related
Chromogranin A Ag in tissue
Specific
chromogranin A precursor
chromostatin
pancreastatin
General
chromogranin; secretogranin;granin
glycoprotein
phosphoprotein
protein precursor
Properties
SIZE: entity length = 457 aa
MW = 51 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-18}
cysteine residue {C35}
MODIFICATION: cysteine residue {C56}
O-glycosylated at one site only in CSF {41-59}
MOTIF: cysteine residue {C56}
MODIFICATION: cysteine residue {C35}
Ser phosphorylation site {S112}
Ser phosphorylation site {S113}
Ser phosphorylation site {S136}
Ser phosphorylation site {S142}
O-glycosylated at one site only in CSF {181-191}
MOTIF: Thr glycosylation site {T181}
Thr glycosylation site {T183}
Ser phosphorylation site {S203}
Ser phosphorylation site {S218}
Thr glycosylation site {T251}
Ser phosphorylation site {S270}
Ser phosphorylation site {S300}
Ser phosphorylation site {S322}
Ser phosphorylation site {S333}
Ser phosphorylation site {S402}
PRECURSOR-FOR: pancreastatin
chromostatin
MISC-INFO: ISOELECTIC_POINT 4.9
Database Correlations
OMIM 118910
UniProt P10645
Pfam PF01271
Entrez Gene 1113
Kegg hsa:1113
References
- Huttner WB, Gerdes HH, Rosa P.
The granin (chromogranin/secretogranin) family.
Trends Biochem Sci. 1991 Jan;16(1):27-30. Review.
PMID: 2053134
- Cetin Y et al
Chromostatin, a chromogranin A-derived bioactive peptide, is
present in human pancreatic insulin (beta) cells.
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2360-4.
PMID: 8096340
- Ross CA, McInnis MG, Margolis RL, Li SH.
Genes with triplet repeats: candidate mediators of
neuropsychiatric disorders.
Trends Neurosci. 1993 Jul;16(7):254-60. Review.
PMID: 7689767
- Entrez Gene :accession 1113
- UniProt :accession P10645