chromogranin; secretogranin;granin

A family of acidic secreted proteins. Expression: - found in secretory vesicles of neurons & endocrine cells secreting neuropeptides & peptide hormones

Specific

chromogranin-A; CgA; secretogranin-A; pituitary secretory protein I; SP-I; contains: vasostatin-1; vasostatin-2; EA-92; ES-43; pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37 (CHGA) Clusterin; Aging-associated gene 4 protein; apolipoprotein J; apo-J; complement cytolysis inhibitor; CLI; complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; testosterone-repressed prostate message 2; TRPM-2; contains: Clusterin beta chain; apoJalpha; complement cytolysis inhibitor a chain; contains: Clusterin alpha chain; apoJbeta; complement cytolysis inhibitor b chain (CLU, APOJ, CLI, KUB1, AAG4) neuroendocrine protein 7B2; pituitary polypeptide; secretogranin V; secretogranin-5; secretory granule endocrine protein I; contains: N-terminal peptide; C-terminal peptide (SCG5, SGNE1) secretogranin-1; chromogranin-B; CgB; secretogranin I; SgI; contains: GAWK peptide; CCB peptide (CHGB, SCG1) secretogranin-2; chromogranin-C; secretogranin II; SgII; contains: secretoneurin; SN (SCG2, CHGC) secretogranin-3; secretogranin III; SgIII (SCG3)

Properties

COMPARTMENT: extracellular compartment MOTIF: acidic region MOTIF: acidic residue (SEVERAL) cysteine residue {X} MODIFICATION: cysteine residue {C-TERMINAL} cysteine residue {C-TERMINAL} MODIFICATION: cysteine residue {X}

References

- Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci. 1991 Jan;16(1):27-30. Review. PMID: 2053134