chromodomain-helicase-DNA-binding protein 1-like (amplified in liver cancer protein 1, CHD1L, ALC1)

Function: - putative DNA helicase, which may play a role in chromatin-remodeling - in vitro, promotes cell proliferation & inhibits apoptois Structure: - belongs to the SNF2/RAD54 helicase family - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain - contains 1 macro domain Compartment: nucleus Alternative splicing: named isoforms=4 Expression: - frequently overexpressed in hepatomacellular carcinomas

General

enzyme nuclear protein phosphoprotein

Properties

SIZE: entity length = 897 aa MW = 101 kD COMPARTMENT: cell nucleus MOTIF: helicase NAME: helicase SITE: 58-223 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 71-78 DEAD/H box NAME: DEAD/H box SITE: 174-177 Helicase C-terminal {351-513} Ser phosphorylation site {S636} coiled coil {638-675} Macro {704-897}

Database Correlations

UniProt Q86WJ1 PFAM correlations Kegg hsa:9557

References

UniProt :accession Q86WJ1