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chromobox protein homolog 7 (CBX7)
Function:
- role in maintaining the transcriptionally repressive state of genes
- modifies chromatin, rendering it heritably changed in its expressibility (putative)
- regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity
- component of a chromatin-associated polycomb complex (PcG) (putative)
- interacts with RING1, but not with BMI1, EED or EZH2
Structure: contains 1 chromo domain
Compartment: nucleus
General
chromobox protein homolog
Properties
SIZE: entity length = 251 aa
MW = 28 kD
COMPARTMENT: cell nucleus
MOTIF: chromodomain
NAME: chromodomain
SITE: 11-69
FOR-BINDING-OF: heterochromatin
cellular longevity {223-236}
Database Correlations
OMIM 608457
UniProt O95931
Pfam PF00385
Entrez Gene 23492
Kegg hsa:23492
References
UniProt :accession O95931