chromatin-remodeling SRCAP complex

Function: - mediates ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling Structure: - subunits: SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 & ZNHIT

Properties

COMPARTMENT: cell nucleus SUBUNITS: Helicase SRCAP COMPARTMENT: cell nucleus MOTIF: HSA {124-196} Ser phosphorylation site {S248} proline-rich region SITE: 275-278 MOTIF: proline residue (SEVERAL) glutamate-rich region {293-563} MOTIF: glutamate residue (SEVERAL) helicase NAME: helicase SITE: 630-795 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 643-650 proline-rich region SITE: 981-1883 MOTIF: proline residue (SEVERAL) active site MOTIF: P-loop FOR-BINDING-OF: adenosine triphosphate Helicase C-terminal {2044-2197} glutamate-rich region {2227-2362} MOTIF: glutamate residue (SEVERAL) Thr phosphorylation site {T2258} proline-rich region SITE: 2426-3023 MOTIF: proline residue (SEVERAL) A+T hook SITE: 2857-2869 Ser phosphorylation site {S2869} A+T hook SITE: 2936-2948 A+T hook SITE: 3004-3016 Ser phosphorylation site {S3148} glutamate-rich region {3179-3182} MOTIF: glutamate residue (SEVERAL) DNA methyltransferase 1-associated protein 1 COMPARTMENT: cell nucleus MOTIF: SANT {149-199} coiled coil {225-275} Thr phosphorylation site {T445} Ser phosphorylation site {S448} serine-rich region {454-460} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S456} RuvB-like 1 COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 70-77 RuvB-like 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 77-84 Ser phosphorylation site {S220} actin-like protein 6A COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S233} YEATS domain-containing protein 4 COMPARTMENT: cell nucleus MOTIF: YEATS {22-126} MLLT10 interaction {163-227} MOTIF: TACC1 interaction {168-227} coiled coil {178-226} YL1 tumor suppressor protein COMPARTMENT: cell nucleus MOTIF: acidic region {22-77} MOTIF: acidic residue (SEVERAL) DNA-binding motif SITE: 156-206 MOTIF: Thr phosphorylation site {T168} proline-rich region SITE: 333-354 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 341-350 MOTIF: proline residue (SEVERAL) actin-related protein 6 COMPARTMENT: cytoplasm ZNHIT

References

UniProt :accession Q9H2G4

Components

actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K) actin-related protein 6; hArp6; hARPX (ACTR6, CDA12) DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1 (DMAP1, KIAA1425) Helicase SRCAP (Snf2-related CBP activator, domino homolog 2, SRCAP, KIAA0309) RuvB-like 1 (49-kD TATA box-binding protein-interacting protein, 49 kD TBP-interacting protein, TIP49a, Pontin 52, nuclear matrix protein 238, NMP 238, 54 kD erythrocyte cytosolic protein, ECP-54, TIP60-associated protein 54-alpha, TAP54-alpha, RUVBL1, NMP238, TIP49, TIP49A) RuvB-like 2 (48-kD TATA box-binding protein-interacting protein, 48 kD TBP-interacting protein, TIP49b, repressing pontin 52, Reptin 52, 51 kD erythrocyte cytosolic protein, ECP-51, TIP60-associated protein 54-beta, TAP54-beta, RUVBL2, TIP48, TIP49B, CGI-46) YEATS domain-containing protein 4 (glioma-amplified sequence-41, Gas41, NuMA binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41) YL1 tumor suppressor protein (vacuolar protein sorting protein 72, transcription factor-like 1, protein YL-1, VPS72, TCFL1, YL1)