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chrfam7a gene
A segmental duplication of chromosome 15 involving CHRNA7 & Fam7A is one of the few features distinguishing the human genome from the chimpanzee genome. [1,2]
CHRFAM7Ais the fusion gene.
FAM7A is a member of the family of sequence similarity 7 genes of unknown function.
General
evolutionary divergent human gene
Properties
LOCUS: human chromosome-15 Q13.1
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 118511
Entrez Gene 1139
References
- Riley B, Williamson M, Collier D, Wilkie H, Makoff A.
A 3-Mb map of a large Segmental duplication overlapping the
alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human
15q13-q14.
Genomics. 2002 Feb;79(2):197-209.
PMID: 11829490
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L,
Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-
Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM.
Lineage-specific gene duplication and loss in human and great
ape evolution.
PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13.
PMID: 15252450