chorion-specific transcription factor GCMa (glial cells missing homolog 1, GCM motif protein 1, hGCMa, GCM1, GCMA)

Function: 1) transcription factor necessary for placental development 2) binds to trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer Structure: - contains 1 GCM DNA-binding domain Compartment: nucleus Expression: placenta specific

General

DNA-binding protein metalloprotein transcription factor (TF)

Properties

SIZE: MW = 49 kD entity length = 436 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 14-169 MOTIF: Zn+2-binding site SITE: 76-76 Zn+2-binding site SITE: 82-82 Zn+2-binding site SITE: 86-86 Zn+2-binding site SITE: 113-113 Zn+2-binding site SITE: 116-116 Zn+2-binding site SITE: 125-125 Zn+2-binding site SITE: 152-152 Zn+2-binding site SITE: 154-154

Database Correlations

OMIM 603715 UniProt Q9NP62 Pfam PF03615

References

UniProt :accession Q9NP62