chordin (CHRD)

Function: - dorsalizing factor - developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) & sequestering them in latent complexes (putative) - cleaved by BMP1; cleavage participates to dorsoventral patterning during early development (putative) - interacts with TWSG1 &/or BMP4 (putative) Structure: - belongs to the chordin family - contains 4 CHRD domains - contains 4 VWFC domains Compartment: secreted (putative) Alternative splicing: - named isoforms=5 - at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay Expression: expressed at the highest level in liver

General

glycoprotein secreted protein

Properties

SIZE: entity length = 955 aa MW = 102 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-26} VWFC domain {49-126} CHRD 1 {168-277} MOTIF: N-glycosylation site {N217} CHRD 2 {279-402} MOTIF: N-glycosylation site {N351} N-glycosylation site {N365} CHRD 3 {403-524} MOTIF: N-glycosylation site {N434} CHRD 4 {530-650} VWFC domain {703-763} VWFC domain {784-850} VWFC domain {872-932}

Database Correlations

OMIM 603475 UniProt Q9H2X0 PFAM correlations Entrez Gene 8646 Kegg hsa:8646

References

UniProt :accession Q9H2X0