chondroadherin; cartilage leucine-rich protein (CHAD, SLRR4A)

Function: - promotes attachment of chondrocytes, fibroblasts, & osteoblasts; binding is mediated (at least for chondrocytes & fibroblasts) by the integrin alpha(2)beta(1) - may play role in the regulation of chondrocyte growth & proliferation (putative) - mostly monomeric (putative) - interacts with collagen type 2 Structure: - belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily - contains 11 LRR repeats (leucine-rich repeats) Compartment: - secreted, extracellular space, extracellular matrix (putative) Expression: - present in chondrocytes at all ages

General

glycoprotein leucine-rich repeat-containing protein (LRRC) secreted protein

Properties

SIZE: entity length = 359 aa MW = 40 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-22} cysteine residue {C23} MODIFICATION: cysteine residue {C38} cysteine residue {C38} MODIFICATION: cysteine residue {C23} leucine-rich repeat SITE: 50-73 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 74-97 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 99-121 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 122-145 MOTIF: leucine residue (SEVERAL) Ser glycosylation site {S144} leucine-rich repeat SITE: 147-169 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 171-193 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 194-217 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 218-241 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 243-266 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 267-290 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 292-317 MOTIF: leucine residue (SEVERAL) cysteine residue {C304} MODIFICATION: cysteine residue {C346} cysteine residue {C306} MODIFICATION: cysteine residue {C326} cysteine residue {C326} MODIFICATION: cysteine residue {C306} cysteine residue {C346} MODIFICATION: cysteine residue {C304}

Database Correlations

OMIM 602178 UniProt O15335 PFAM correlations Entrez Gene 1101 Kegg hsa:1101

References

UniProt :accession O15335