Search
choline/ethanolamine kinase; choline kinase beta; CKB; choline kinase-like protein; ethanolamine kinase; EK; ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB (CHKB, CHETK, CHKL)
Function:
- role in phospholipid biosynthesis
- catalyzes 1st step in phosphatidylethanolamine biosynthesis
- phosphorylates ethanolamine
- phosphorylates choline with lesser efficiency (contribution to phosphatidylcholine biosynthesis probably not significant)
- phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3
- homodimer, & heterodimer with CHKA
ATP + ethanolamine = ADP + O-phosphoethanolamine ATP + choline = ADP + O-phosphocholine
Kinetic parameters:
- KM=0.57 mM for choline
- KM=2.9 mM for ethanolamine
Structure: belongs to the choline/ethanolamine kinase family
Alternative splicing: named isoforms=2
Notes:
- protein produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame
Related
choline kinase (CHKA)
ethanolamine kinase 1; EKI 1 (ETNK1, EKI1)
General
kinase or ATP-phosphotransferase
phosphoprotein
Properties
SIZE: entity length = 395 aa
MW = 45 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S39}
Ser phosphorylation site {S42}
ATP-binding site
NAME: ATP-binding site
SITE: 75-81
MOTIF: Substrate binding {77-79}
ATP-binding site
NAME: ATP-binding site
SITE: 104-104
ATP-binding site
NAME: ATP-binding site
SITE: 146-152
ATP-binding site
NAME: ATP-binding site
SITE: 244-244
ATP-binding site
NAME: ATP-binding site
SITE: 264-264
Database Correlations
OMIM 612395
UniProt Q9Y259
Pfam PF01633
Entrez Gene 1120
Kegg hsa:1120
ENZYME correlations
References
UniProt :accession Q9Y259