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choline-phosphate cytidylyltransferase B; CCT-beta; CTP:phosphocholine cytidylyltransferase B; CCT B; CT B; phosphorylcholine transferase B (PCYT1B, CCTB)
Function:
- controls phosphatidylcholine synthesis
- phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2
- extensively phosphorylated
- the beta-1 isoform seems to be much less phosphorylated
CTP + choline phosphate = diphosphate + CDP-choline
Structure: belongs to the cytidylyltransferase family
Compartment: endoplasmic reticulum
Alternative splicing: named isoforms=2 or 3
Expression:
- highly expressed in testis, placenta, brain, ovary & fetus
General
nucleotidyltransferase
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 369 aa
MW = 42 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: active site
SITE: 74-235
MOTIF: Ser phosphorylation site {S233}
Ser phosphorylation site {S315}
Ser phosphorylation site {S319}
Thr phosphorylation site {T325}
Database Correlations
OMIM 604926
UniProt Q9Y5K3
Pfam PF01467
Entrez Gene 9468
KEGG correlations
ENZYME 2.7.7.15
References
- UniProt :accession Q9Y5K3
- SeattleSNPs
http://pga.gs.washington.edu/data/pcyt1b/