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choline-phosphate cytidylyltransferase A; CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; phosphorylcholine transferase A (PCYT1A, CTPCT, PCYT1)
Function:
- controls phosphatidylcholine synthesis
- phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2
- Ser of the C-terminus are phosphorylated
- inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, & is stabilized by dephosphorylation
CTP + choline phosphate = diphosphate + CDP-choline
Structure:
- homodimer; disulfide-linked
- belongs to the cytidylyltransferase family
Compartment:
- cytoplasm, cytosol (putative)
- peripheral membrane
- interconverts between an inactive cytosolic form & an active membrane-bound form (putative)
General
nucleotidyltransferase
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 367 aa
MW = 42 kD
COMPARTMENT: cytoplasm
MOTIF: cysteine residue {C37}
MODIFICATION: cysteine residue {C-INTERCHAIN}
active site
SITE: 74-235
Amphipathic {228-287}
3 X 11 AA approximate tandem repeats {256-288}
Ser phosphorylation site {S315}
3 X repeats {319-348}
MOTIF: consensus repeat {319-324}
Ser phosphorylation site {S319}
Ser phosphorylation site {S321}
Thr phosphorylation site {T325}
consensus repeat {329-333}
Ser phosphorylation site {S329}
Ser phosphorylation site {S331}
Ser phosphorylation site {S339}
Thr phosphorylation site {T342}
consensus repeat {343-348}
Ser phosphorylation site {S343}
Ser phosphorylation site {S347}
Ser phosphorylation site {S352}
Ser phosphorylation site {S362}
Database Correlations
OMIM 123695
UniProt P49585
Pfam PF01467
Entrez Gene 5130
KEGG correlations
ENZYME 2.7.7.15
References
- UniProt :accession P49585
- SeattleSNPs
http://pga.gs.washington.edu/data/pcyt1a/