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cholesteryl ester transfer protein; lipid transfer protein I (CETP)

Function: - exchanges cholesterol ester in HDL for triglyceride in LDL & VLDL - may also catalyze exchange of cholesterol esters between HDL & LDL & catalyze exchange of cholesterol ester in LDL for triglyceride in VLDL [2] Structure: - belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family Compartment: secreted, extracellular space Alternative splicing: named isoforms=2 Expression: expressed by the liver & secreted in plasma Pathology: - defects in CETP are a cause of hyperalphalipoproteinemia type 1 - defects in CETP are the cause of CETP deficiency - deficiency in animals results in resistance to atherosclerosis [1], excess in susceptibility [3] - VV genotype (I405V) in humans promotes longevity & is protective against cognitive decline [4,8,9] Polymorphism: - at least 6 CETP genotypes [5] TaqIB, I405V, -269C>A, D422G, -631C>A, R451Q Pharmacology: - CETP inhibitors lower HDL cholesterol, but may not lower risk of cardiovascular events

Related

cholesteryl ester transfer protein (CETP) inhibitor

General

glycoprotein lipid transfer protein plasma protein

Properties

SIZE: entity length = 493 aa MW = 55 kD COMPARTMENT: plasma MOTIF: signal sequence {1-17} N-glycosylation site {N105} N-glycosylation site {N257} N-glycosylation site {N358} N-glycosylation site {N413}

Database Correlations

OMIM correlations MORBIDMAP 118470 UniProt P11597 PFAM correlations Entrez Gene 1071 Kegg hsa:1071

References

  1. OMIM :accession 188470
  2. Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 30
  3. Marotti et al Nature 364:73 1993
  4. Barzilai N et al, A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006, 67:2170 PMID: 17190939
  5. Thompson A et al, Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels and coronary risk. JAMA 2008, 299:2777 PMID: 18560005
  6. SHMPD, The Singapore human mutation & polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CETP
  7. Wikipedia, Cholesterylester transfer protein entry http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein
  8. Sanders AE et al. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA 2010 Jan 13; 303:150 PMID: 20068209
  9. Soerensen M et al Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. PMID: 2223486