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cholesterol 25-hydroxylase; cholesterol 25-monooxygenase; h25OH (CH25H)
Function:
1) catalyzes the formation of 25-hydroxycholesterol from cholesterol, inhibiting cholesterol biosynthesis
2) regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing
3) Leydig cell differentiation in testis
Structure:
- N-glycosylated
- belongs to the sterol desaturase family
Compartment: endoplasmic reticulum
Pathology:
- Not associated with susceptibility to Alzheimer disease
Related
25-OH-cholesterol
General
glycoprotein
hydroxylase; monooxygenase
transmembrane 3 protein
Properties
SIZE: entity length = 272 aa
MW = 32 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: N-glycosylation site {N5}
transmembrane domain {38-58}
transmembrane domain {84-104}
transmembrane domain {121-141}
Histidine box-1 {142-146}
Histidine box-2 {157-161}
N-glycosylation site {N163}
N-glycosylation site {N189}
Histidine box-3 {238-244}
Database Correlations
OMIM 604551
UniProt O95992
Pfam PF04116
Entrez Gene 9023
Kegg hsa:9023
ENZYME 1.14.99.38
References
UniProt :accession O95992