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cholestatic hepatitis
Etiology:
- viral hepatitis
- hepatitis A
- hepatitis B
- hepatitis C
- pharmaceutical agents
- alcoholic hepatitis
- congestive heart failure
- chronic pancreatitis
- Hodgkin's disease
- fatty liver
Clinical manifestations:
- jaundice
- pruritus
- hepatomegaly
- fatigue
- indigestion
Laboratory:
- serum direct bilirubin is elevated
- serum bile acids elevated 10-20 fold
- serum alkaline phosphatase is elevated
- serum gamma-glutamyltransferase is elevated
- serum 5'nucleotidase is elevated
- serum ALT is moderately elevated
- serum cholesterol is elevated
Special laboratory:
- abdominal ultrasound
Management:
- treat underlying etiology
- nutrition
a) low fat, low cholesterol diet
b) vitamin supplementation (especially fat-souble vitamins)
- cholestyramine may help reduce itch (see cholestatis)
General
hepatitis
cholestasis
References
- Zhang Clinic
http://www.sinomedresearch.org/CholesHep/Cholestatic.htm