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cholera vaccine (Vibrio cholerae vaccine, Shanchol, Vaxchora)
Vaxchora FDA-approved June 2016
Indications:
- immunization against Vibrio cholerae infection (cholera)
- prevention of cholera (serogroup O1) in adults aged 18-64 years visiting cholera-affected areas [3,4]
Contraindications:
- Vaxchora's safety & effectiveness not established in immunocompromised patients [3]
Dosage:
- oral cholera vaccine Shanchol [2]
- 2 doses at least 14 days apart
- 37% effective for 1 dose, > 50% effective for 2 doses
- Vaxchora: single liquid dose (~ 3 oz) at least 10 days before travel [3]
Adverse effects:
- fatigue, headache
- abdominal pain, nausea/vomiting, appetite loss, diarrhea
Drug interactions:
- antibiotics in the prior 14 days may interfere with the vaccine [4]
- delay chloroquine until >= 10 days after vaccination [4]
Mechanism of action:
- Shanchol: bivalent whole-cell inactivated vaccine
Related
cholera
Vibrio cholerae
General
live virus vaccine
References
- CPT
- Qadri F et al
Feasibility and effectiveness of oral cholera vaccine in an
urban endemic setting in Bangladesh: a cluster randomised
open-label trial.
Lancet. July 8, 2015
PMID: 26164097
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2961140-0/abstract
- O'Leary M, Mulholland K
Oral cholera vaccines in endemic countries.
Lancet. July 8, 2015
PMID: 26164098
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960246-X/abstract
- FDA News Release. June 10, 2016
FDA approves vaccine to prevent cholera for travelers.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm506305.htm
- Wong KK, Burdette E, Mahon BE, Mintz ED, Ryan ET, Reingold AL.
Recommendations of the Advisory Committee on Immunization
Practices for Use of Cholera Vaccine.
MMWR Morb Mortal Wkly Rep 2017;66:482-485
https://www.cdc.gov/mmwr/volumes/66/wr/mm6618a6.htm