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cholecystokinin receptor type A; CCK-A receptor; CCK-AR; cholecystokinin-1 receptor; CCK1-R (CCKAR, CCKRA)
Function:
- receptor for cholecystokinin
- mediates pancreatic growth & enzyme secretion
- mediates smooth muscle contraction of the gall bladder & stomach
- affinity 1000-fold higher for CCK than for gastrin
- modulates feeding & dopamine-induced behavior in the central nervous system & peripheral nervous system
- mediates its action via G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
General
cholecystokinin [CCK] receptor
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 428 aa
MW = 48 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-41}
MOTIF: N-glycosylation site {N10}
cysteine residue {C18}
MODIFICATION: cysteine residue {C29}
N-glycosylation site {N24}
cysteine residue {C29}
MODIFICATION: cysteine residue {C18}
transmembrane domain {42-67}
cytoplasmic loop {68-77}
transmembrane domain {78-104}
exoplasmic loop {105-115}
MOTIF: cysteine residue {C114}
MODIFICATION: cysteine residue {C196}
transmembrane domain {116-137}
cytoplasmic loop {138-157}
transmembrane domain {158-178}
exoplasmic loop {179-210}
MOTIF: N-glycosylation site {N190}
cysteine residue {C196}
MODIFICATION: cysteine residue {C114}
transmembrane domain {211-234}
cytoplasmic loop {235-313}
transmembrane domain {314-334}
exoplasmic loop {335-349}
transmembrane domain {350-373}
cytoplasmic domain {374-428}
MOTIF: cysteine residue {C387}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 118444
UniProt P32238
PFAM correlations
Kegg hsa:886
References
- UniProt :accession P32238
- Wikipedia; Note: cholecystokinin receptor entry
http://en.wikipedia.org/wiki/cholecystokinin_receptor