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cholecystokinin
Function:
- dual action
a) induces gall bladder contraction
b) stimulates exocrine pancreatic enzyme secretion
- function in the brain is not clear
- binding to CCK-A receptors stimulates amylase release from the pancreas
- binding to CCK-B receptors stimulates gastric acid secretion
- precursor is cleaved by proteases to produce a number of active cholecystokinins
- binds to CCK-A receptors in the pancreas & CCK-B receptors in the brain (putative)
Structure:
- CCK occurs in several different molecular forms
- a sulfotyrosine residue is required for biological activity
-
Expression:
- secreted by epithelial cells within the small intestine in response to ingestion of food
Pharmacology:
- sincalide is a synthetically-prepared C-terminal octapeptide of cholecystokinin used as a diagnostic agent
Interactions
molecular events
General
gastrointestinal hormone
secreted protein
Properties
SIZE: entity length = 115 aa
MW = 13 kD
COMPARTMENT: extracellular compartment
SECRETED-BY: epithelial cell
WITHIN: intestine
FORM: procholecystokinin
MOTIF: sulfotyrosine site
MODIFICATION: sulfate
MISC-INFO: 1/2life 2.5-7 MINUTES
Database Correlations
OMIM 118440
UniProt P06307
Pfam PF00918
Entrez Gene 885
Kegg hsa:885
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- UniProt :accession P06307
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cck/
- Wikipedia; Note: cholecystokinin entry
http://en.wikipedia.org/wiki/cholecystokinin