chloride intracellular channel protein 5 (CLIC5)

Function: - can insert into membranes & form poorly selective ion channels that may also transport chloride ions - may play role in regulation of transepithelial ion absorption & secretion - required for normal formation of stereocilia in the inner ear & normal development of the organ of corti (putative) - required for the development &/or maintenance of proper glomerular endothelial cell & podocyte architecture - component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, & IQGAP1 - interacts with AKAP9 Structure: - members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane & functions as chloride channel - a conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (putative) - belongs to the chloride channel CLIC family - contains 1 GST C-terminal domain Compartment: - isoform 1: - cytoplasm, cell cortex, cytoskeleton, membrane - single-pass membrane protein - associates with the cortical actin cytoskeleton - exists both as soluble cytoplasmic protein & as membrane protein - isoform 2 - Golgi, cytoplasm, cytoskeleton, centrosome, membrane - single-pass membrane protein - colocalized with AKAP9 at the Golgi & the centrosome (in part) - exists both as soluble cytoplasmic protein & as membrane protein - colocalized with podocalyxin in renal glomeruli Alternative splicing: named isoforms=2 Expression: - isoform 1: expressed in renal glomeruli endothelial cells & podocytes (at protein level)

Properties

SIZE: entity length = 410 aa MW = 47 kD COMPARTMENT: cytoplasm golgi MOTIF: N-terminal {1-192} transmembrane domain {193-213} GST C-terminal {260-400}

Database Correlations

OMIM 607293 UniProt Q9NZA1 Entrez Gene 53405 Kegg hsa:53405

References

UniProt :accession Q9NZA1