chloride intracellular channel protein 3 (CLIC3)

Function: - can insert into membranes & form chloride ion channels - may participate in cellular growth control - associated with the C-terminal of ERK7 Structure: - members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane & functions as chloride channel - a conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion - belongs to the chloride channel CLIC family - contains 1 GST C-terminal domain - contains 1 GST N-terminal domain Compartment: - nucleus, membrane - single-pass membrane protein - cytoplasm - predominantly nuclear - some protein is found in the cytoplasm - exists both as soluble cytoplasmic protein & as membrane protein with probably a single transmembrane domain (putative) Expression: - detected in placenta (at protein level) - widely expressed - expression in placenta > lung & heart > skeletal muscle, kidney & pancreas

Properties

SIZE: entity length = 236 aa MW = 27 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: cysteine residue {C22} MODIFICATION: cysteine residue {C25} cysteine residue {C25} MODIFICATION: cysteine residue {C22} transmembrane domain {25-44} GST C-terminal {91-235}

Database Correlations

OMIM 606533 UniProt O95833 Entrez Gene 9022 Kegg hsa:9022

References

UniProt :accession O95833