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chloride intracellular channel protein 2; XAP121 (CLIC2)
Function:
- can insert into membranes & form chloride ion channels
- channel activity depends on the pH
- membrane insertion seems to be redox-regulated & may occur only under oxidizing conditions
- modulates the activity of RYR2 & inhibits Ca+2 influx
- monomer, interacts with TRAPPC2 & RYR2
Structure:
- members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane & functions as chloride channel
- a conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion
- belongs to the chloride channel CLIC family
- contains 1 GST C-terminal domain
Compartment:
- cytoplasm, membrane
- single-pass membrane protein (probable)
- exists both as soluble cytoplasmic protein & as membrane protein with probably a single transmembrane domain
Expression:
- expressed in adult brain, heart, liver, lung, spleen, stomach & testis
- expressed in fetal liver & adult skeletal muscle
General
chloride intracellular channel protein (nuclear chloride ion channel)
Properties
SIZE: entity length = 247 aa
MW = 28 kD
COMPARTMENT: cytoplasm
MOTIF: N-terminal {1-94}
MOTIF: cysteine residue {C30}
MODIFICATION: cysteine residue {C33}
transmembrane domain {32-52}
cysteine residue {C33}
MODIFICATION: cysteine residue {C30}
Joint loop {95-106}
C-terminal {107-247}
MOTIF: Foot loop {151-171}
Database Correlations
OMIM 300138
UniProt O15247
Pfam PF00462
Entrez Gene 1193
Kegg hsa:1193
References
UniProt :accession O15247