chloride intracellular channel 6 (CLIC6, CLIC1L)

Function: - probable Cl^- channel - may play a critical role in water-secreting cells, possibly through the regulation of Cl^- transport (putative) - interacts with dopamine receptors DRD2, DRD3 & DRD4 - phosphorylated (putative) Structure: belongs to the chloride channel CLIC family Compartment: - cytoplasm (putative), cell membrane - predominantly cytoplasmic - upon Cl^- efflux from the cell, it is translocated to the plasma membrane (putative) Alternative splicing: named isoforms=2 Expression: expressed in brain, placenta, pancreas & liver

Properties

SIZE: MW = 73 kD entity length = 704 aa COMPARTMENT: cytoplasm MOTIF: consensus repeat {157-166} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {167-176} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {177-186} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {187-196} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {197-206} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {207-216} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {217-226} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {227-236} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {237-246} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {247-256} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {257-266} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {267-276} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP] consensus repeat {277-286} SEQUENCE-IS: G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP]

References

UniProt :accession Q96NY7