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Chimeric POTE-actin protein (POTAC, POTEF)
Structure:
- in the N-terminal section; belongs to the POTE family family contains 5 ANK repeats
Compartment:
- cytoplasm, cell cortex
- colocalizes with actin filaments
Expression:
- expressed in breast cancer cell lines (at protein level)
Genetics:
- results from the insertion of a beta-actin fragment at the C-terminus in the POTE2 paralog gene leading the formation of a new functional chimeric protein
- this insertion occured before the divergence of the Old World monkeys & apes
- in the C-terminal section, belongs to the actin
General
cytoskeletal protein
Properties
SIZE: entity length = 1075 aa
MW = 121 kD
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 172-201
ankyrin repeat
NAME: ankyrin repeat
SITE: 205-234
ankyrin repeat
NAME: ankyrin repeat
SITE: 238-267
ankyrin repeat
NAME: ankyrin repeat
SITE: 271-300
ankyrin repeat
NAME: ankyrin repeat
SITE: 304-333
coiled coil {399-435}
coiled coil {642-698}
Actin-like {702-1075}
Database Correlations
UniProt A5A3E0
PFAM correlations
References
UniProt :accession A5A3E0