chemokine-like receptor 1; G-protein coupled receptor chemR23; G-protein coupled receptor DEZ (CMKLR1, CHEMR23, DEZ)

Function: - orphan receptor - could be a chemotactic peptide receptor - may have a function in bone metabolism Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Alternative splicing: named isoforms=2; A, B Expression: - expressed during bone development in developing osseous & cartilagenous tissue - also found in adult parathyroid Pathology: - acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR & SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)

General

chemokine receptor (chemoattractant receptor) glycoprotein phosphoprotein

Properties

SIZE: entity length = 373 aa MW = 42 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-41} MOTIF: N-glycosylation site {N9} transmembrane domain {42-64} cytoplasmic loop {65-75} transmembrane domain {76-97} exoplasmic loop {98-114} MOTIF: cysteine residue {C112} MODIFICATION: cysteine residue {C189} transmembrane domain {115-135} cytoplasmic loop {136-154} transmembrane domain {155-176} exoplasmic loop {177-224} MOTIF: cysteine residue {C189} MODIFICATION: cysteine residue {C112} N-glycosylation site {N192} transmembrane domain {225-245} cytoplasmic loop {246-261} transmembrane domain {262-282} exoplasmic loop {283-300} transmembrane domain {301-320} cytoplasmic domain {321-373} MOTIF: Ser phosphorylation site {S339} Thr phosphorylation site {T342} Ser phosphorylation site {S349}

Database Correlations

OMIM 602351 UniProt Q99788 Pfam PF00001 Entrez Gene 1240 Kegg hsa:1240

References

UniProt :accession O75748