Chemokine-like factor (C32, CKLF, CKLF1, HSPC224, UNQ410/PRO772)

Function: - role in inflammation & regeneration of skeletal muscle - partly inhibited by interleukin 10 - isoform CKLF1 has chemotactic response in rat monocytes, neutrophils, & lymphocytes Structure: - belongs to the chemokine-like factor family - contains 1 MARVEL domain Compartment: - isoform CKLF1 secreted - isoforms CKLF2, CKLF4 membrane Expression: - all 4 isoforms have highest expression levels in adult spleen, lungs, testis, ovary, peripheral blood leucocyte, placenta, pancreas, & in fetal brain, skeletal muscle, thymus & heart - lower expression levels in adult skeletal muscle, liver, thymus, colon, prostate, & fetal spleen & liver

General

membrane protein secreted protein

Properties

SIZE: MW = 17 kD entity length = 152 aa COMPARTMENT: extracellular compartment MOTIF: MARVEL {13-133} MOTIF: transmembrane domain {45-65} transmembrane domain {81-101} transmembrane domain {108-128}

Database Correlations

UniProt Q9UBR5 Pfam PF01284

References

UniProt :accession Q9UBR5