CGG triplet repeat-binding protein 1 (CGG-binding protein 1, p20-CGGBP DNA-binding protein, 20 kD CGG-binding protein, CGGBP1, CGGBP)

Function: - role in regulating FMR1 promoter - binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter - binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif Compartment: nucleus Expression: - ubiquitous - highly expressed in placenta, thymus, lymph nodes, cerebellum & cerebral cortex - low expression in other regions of the brain - expressed in fetal brain & kidney > fetal liver & lung

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 19 kD entity length = 167 aa COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {80-84} DNA-binding motif

Database Correlations

OMIM 603363 UniProt Q9UFW8

References

UniProt :accession Q9UFW8