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cerebrospinal fluid (CSF) protein electrophoresis
CSF protein electrophoresis (after concentration)
Indications:
1) used largely to detect intrathecal production of IgG
a) IgG/albumin ratio < 0.27 considered normal
b) multiple sclerosis
2) beta-2 transferrin presence used for establishing CSF leakage
Reference interval:
analyte %* value plasma/CSF ratio
total protein - 5-24 mg/dL -
- prealbumin 2-7% 17.3 mg/L 14
- albumin 56-76% 155 mg/L 260
- alpha-1 globulin 2-7% - -
- alpha-2 globulin 4-12% - -
- beta globulin 8-18% - -
- gamma globulin 3-12% - -
* % of total protein CSF analysis>
Characteristics:
1)
CSF is an ultrafiltrate of
plasma
2) all proteins visible on
electrophoresis are <150
kD
3) prominent
prealbumin band
4) 2
transferrin bands
a)
beta-1 transferrin
b)
beta-2 transferrin (
CSF-specific
transferrin)
Related
cerebrospinal fluid
cerebrospinal fluid analysis
Specific
monoclonal protein in CSF
oligoclonal banding in CSF (high-resolution CSF protein electrophoresis)
oligoclonal bands in serum&CSF
General
protein electrophoresis
special chemistry test
References
- Fundamentals of Clinical Chemistry 3rd ed., N.W.
Teitz ed., W.B. Saunders, 1988, pg 339
- Saunders Manual of Medical Practice, Rakel (ed),
WB Saunders, Philadelphia, 1996, pg 1065-67
- Tietz Textbook of Clinical Chemistry, 2nd ed.
Burtis CA & Ashwood ER (eds), WB Saunders Co,
Philadelphia PA, 1993
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996