Search
cerebrolysin
- neuroeptide mixture from purified brain extracts by enzymatic breakdown
- porcine-derived collection of growth factors [5]
Function:
1) has nerve growth factor like activity on DRG neurons
Indications:
- Alzheimer's disease
- parent peptide of N-PEP-12 (MemoProve)
- stroke-related aphasia [5]
Dosage:
- 30 mL/day cerebrolysin intravenous infusion with 0.9% saline
- administered for 30 days over a 3 month perior
Mechanism of action:
1) unknown, effects may be longer lasting than drug itself [1]
2) may inhibit apoptosis [2]
3) induces expression of blood brain barrier glucose transporter expression [3]
4) improves synaptic plasticity & behavioral performance in a mouse model for Alzheimer's disease [4]
Related
N-PEP-12 (MemoProve)
General
pharmacologic combination
References
- Crook TH et al,
Effects of N-PEP-12 on memory among older adults
In Clin Psychoparmacol 2005, 20:97
PMID: 15729085
- Deigner HP et al,
Apoptosis modulators in the therapy of neurodegenerative
diseases.
Expert Opin Investig Drug 2000, 9:747
PMID: 11060707
- Windisch M
Approach towards an integrative drug treatment of Alzheimer's
disease.
J Neural Transm Suppl 2000, 59:301
PMID: 10961442
- Rockenstein E et al,
Effects of Cerebrolysin on neurogenesis in an APP transgenic
mouse model of Alzheimer's disease.
Acta Neuropathol (Berl) 2007, 113:265
PMID: 17131129
- Bosworth T
Old Drug a New Option for Stroke-Related Aphasia?
Mesdcape.Oct 28, 2024
https://www.medscape.com/viewarticle/old-drug-new-option-stroke-related-aphasia-2024a1000jn5