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ceramide kinase; hCERK; acylsphingosine kinase; lipid kinase 4; LK4 (CERK, KIAA1646)
Function:
- phosphorylation of ceramide to form ceramide 1-phosphate
Structure: contains 1 DAGKc domain
Compartment: cytoplasm & membrane-associated
Expression:
- expressed in heart, brain, skeletal muscle, kidney & liver > leukocytes, thymus > spleen, small intestine, placenta, lung
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 537 aa
MW = 60 kD
COMPARTMENT: cytoplasm
MOTIF: sulfatide/phosphoinositide binding {1-125}
DAGKc {128-278}
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
OMIM 610307
UniProt Q8TCT0
Pfam PF00781
Entrez Gene 64781
Kegg hsa:64781
ENZYME 2.7.1.138
References
UniProt :accession Q8TCT0