centrosome-associated protein 350 (centrosome-associated protein 350, CEP350, CAP350, GM133)

Function: - required for anchoring microtubules to the centrosomes - required for the integrity of the microtubule network - recruits PPARA to discrete subcellular compartments & thus modulates PPARA activity - component of a ternary complex that contains CEP350, FGFR1OP & MAPRE1 - interacts directly with FGFR1OP via its C-terminus - interacts with NR1H3, PPARA, PPARD & PPARG - phosphorylated during mitosis Strucutre: contains 1 CAP-Gly domain Compartment: - centrosome, spindle, nucleus - associated with mitotic spindles - nuclear, in discrete foci - associated with intermediate filaments Expression: - detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney, pancreas

General

cytoskeletal protein nuclear protein phosphoprotein

Properties

SIZE: MW = 351 kD entity length = 3117 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {598-645} serine-rich region {1112-1281} MOTIF: serine residue (SEVERAL) coiled coil {1369-1411} serine-rich region {1502-1556} MOTIF: serine residue (SEVERAL) coiled coil {1707-1800} Ser phosphorylation site {S1818} coiled coil {1856-1899} coiled coil {2051-2110} CAP/Gly domain {2517-2559} MOTIF: glycine residue (SEVERAL) coiled coil {2719-2752}

Database Correlations

UniProt Q5VT06 Pfam PF01302

References

UniProt :accession Q5VT06