centrosomal protein of 170 kD (KARP-1-binding protein, KARP1-binding protein, CEP170, FAM68A, KAB, KIAA0470)

Function: - role in microtubule organization - interacts with PLK1 - phosphorylated; probably by PLK1 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the CEP170 family - contains 1 FHA domain Compartment: - centrosome, centriole - associated with the mature mother centriole - associated with spindle microtubules during mitosis Alternative splicing: named isoforms=3

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 175 kD entity length = 1584 aa COMPARTMENT: cytoplasm MOTIF: forkhead-associated (FHA) domain {23-73} Ser phosphorylation site {S356} Ser phosphorylation site {S359} Thr phosphorylation site {T377} Ser phosphorylation site {S630} Ser phosphorylation site {S633} Ser phosphorylation site {S636} Ser phosphorylation site {S838} Targeting to microtubules {853-1584} MOTIF: Ser phosphorylation site {S879} Ser phosphorylation site {S1112} Targeting to centrosomes {1113-1584} Ser phosphorylation site {S1260} coiled coil {1467-1495}

Database Correlations

UniProt Q5SW79 Pfam PF00498

References

UniProt :accession Q5SW79