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centrosomal protein of 70 kD; Cep70; p10-binding protein (CEP70, BITE)
Function:
- plays a role in the organization of both preexisting & nascent microtubules in interphase cells
- during mitosis, required for the organization & orientation of the mitotic spindle
- directly interacts with tubulin-gamma
- this interaction determines centrosomal localization
Structure:
- the coiled-coil domains may be important for tubulin-gamma binding & hence for centrosomal localization
- contains 1 TPR repeat
Compartment:
- cytoplasm, cytoskeleton, centrosome
- localized at the center of the radial microtubule array in interphase & at the spindle poles during various stages of mitosis
Alternative splicing: named isoforms=5
General
centrosomal protein
Properties
SIZE: entity length = 597 aa
MW = 70 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {75-179}
coiled coil {254-326}
tetratricopeptide repeat {483-516}
Database Correlations
OMIM 614310
UniProt Q8NHQ1
Entrez Gene 80321
Kegg hsa:80321
References
UniProt :accession Q8NHQ1