centrosomal protein of 57 kD; Cep57; FGF2-interacting protein; testis-specific protein 57; translokin (CEP57, KIAA0092, TSP57)

Function: - centrosomal protein - may be required for microtubule attachment to centrosomes - may act by forming ring-like structures around microtubules - mediates nuclear translocation & mitogenic activity of the internalized growth factor FGF2 (putative) - interacts with microtubules - interacts with FGF2 & RAP80 - does not interact with FGF1 or FGF2 isoform 24 kD Structure: - homodimer & homooligomer - the C-terminal region mediates interaction with microtubules & is able to nucleate & bundles microtubules in vitro (putative) - the centrosome localization domain (CLD) region mediates the localization to centrosomes & homooligomerization - belongs to the translokin family Compartment: - nucleus (putative) - cytoplasm, cytoskeleton, centrosome Alternative splicing: named isoforms=4 Expression: ubiquitous Pathology: - defects in CEP57 are the cause of mosaic variegated aneuploidy syndrome type 2

General

centrosomal protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 500 aa MW = 57 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S53} CLD {58-239} coiled coil {63-242} lysine-rich region {260-265} MOTIF: lysine residue (SEVERAL) domain {277-491} MOTIF: Ser phosphorylation site {S388} coiled coil {392-492}

Database Correlations

OMIM correlations UniProt Q86XR8 PFAM correlations Entrez Gene 9702 Kegg hsa:9702

References

UniProt :accession Q86XR8